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ea0086s2.1 | Drugable hormones and their receptors: past, present and future. Are we running out of targets? Are there more hormones to find? | SFEBES2022

Therapeutic potential of an old friend – the dichotomy of amylin in physiology and pathophysiology

Lutz Thomas

The mature 37 amino acid peptide amylin is derived from the IAPP (islet amyloid polypeptide) gene and is produced in pancreatic beta-cells and in much lower amounts in other tissues, like the stomach, spinal ganglia and in the brain. Amylin is characterized by an interesting dichotomy because amylin has to propensity to aggregate into fibrils in some species, but on the other hand also to the physiological control of metabolism (probably in all species). These di...

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ea0037ep515 | Diabetes (complications & therapy) | ECE2015

Roux-en-Y gastric bypass reduces proteinuria in diabetic kidney disease to a greater extent than weight loss alone in the Zucker diabetic fatty rat without a greater improvement in renal inflammation

Neff Karl , Elliott Jessie , Jackson Sabrina , Abegg Kathrin , Corteville Caroline , Munoz Rodrigo , Docherty Neil , Lutz Thomas , le Roux Carel

Background: The effect of Roux-en-Y gastric bypass (RYGB) on diabetic kidney disease (DKD) is unclear. We used a Zucker diabetic fatty rat (ZDF) model of DKD to determine the effect of RYGB on histopathological markers of DKD, proteinuria, and MCP1 excretion.Methods: ZDF rats underwent RYGB (n=15) or sham surgery (n=14) at 18 weeks of age. Eight sham operated animals were food restricted to match the weight loss of the RYGB group (body-...

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Endocrine Abstracts

Therapeutic potential of an old friend – the dichotomy of amylin in physiology and pathophysiology

Roux-en-Y gastric bypass reduces proteinuria in diabetic kidney disease to a greater extent than weight loss alone in the Zucker diabetic fatty rat without a greater improvement in renal inflammation

BiosciAbstracts